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The antibody against AIP was raised in rabbit using the Recombinant Human AH receptor-interacting protein (105-294AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against AIP was raised in rabbit using the Recombinant Human AH receptor-interacting protein (105-294AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human adrenal gland tissue using AIP Antibody at dilution of 1:100
| Cat.No | ADC-09297A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AIP |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human AH receptor-interacting protein (105-294AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O00170 |
Uniprot Id
O00170
Target Species
Human
Target Name
AIP
Target Full Name
AH receptor-interacting protein
Target Function
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.; Cellular negative regulator of the hepatitis B virus (HBV) X protein.
Target Involvement
Pituitary adenoma 1, multiple types (PITA1); Prolactin-secreting pituitary adenoma (PSPA)
Target Subcellular Location
Cytoplasm.
Target Tissue Specificity
Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.
Target Synonyms
AH receptor interacting protein; AH receptor-interacting protein; AIP; AIP_HUMAN; ARA 9; ARA9; Aryl hydrocarbon receptor interacting protein; Aryl-hydrocarbon receptor-interacting protein; fa03h10; FKBP 16; FKBP 37; FKBP16; FKBP37; HBV X associated protein 2; HBV X associated protein; HBV X-associated protein 2; HBVX associated protein ; Immunophilin homolog ARA 9; Immunophilin homolog ARA9; SMTPHN; XAP 2; XAP-2; XAP2
Target Background
The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene.
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