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The antibody against ALOX12B was raised in rabbit using the Recombinant Human Arachidonate 12-lipoxygenase, 12R-type protein (484-663AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against ALOX12B was raised in rabbit using the Recombinant Human Arachidonate 12-lipoxygenase, 12R-type protein (484-663AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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| Cat.No | ADC-02266A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ALOX12B |
| Target Synonyms | ALOX12B antibody; Arachidonate 12-lipoxygenase antibody; 12R-type antibody; 12R-LOX antibody; 12R-lipoxygenase antibody; EC 1.13.11.- antibody; Epidermis-type lipoxygenase 12 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Arachidonate 12-lipoxygenase, 12R-type protein (484-663AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O75342 |
Uniprot Id
O75342
Target Species
Human
Target Name
ALOX12B
Target Full Name
Arachidonate 12-lipoxygenase, 12R-type
Target Function
Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.
Target Involvement
Ichthyosis, congenital, autosomal recessive 2 (ARCI2)
Target Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region.
Target Protein Families
Lipoxygenase family
Target Tissue Specificity
Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin. Also expressed in psoriatic tissue.
Target Synonyms
ALOX12B; Arachidonate 12-lipoxygenase; 12R-type; 12R-LOX; 12R-lipoxygenase; EC 1.13.11.-; Epidermis-type lipoxygenase 12
Target Background
This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.
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