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The antibody against APH1B was raised in rabbit using the Peptide sequence from Human Gamma-secretase subunit APH-1B protein (93-110AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against APH1B was raised in rabbit using the Peptide sequence from Human Gamma-secretase subunit APH-1B protein (93-110AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
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Western Blot | Positive WB detected in: SH-SY5Y whole cell lysate, PC-3 whole cell lysate | All lanes: APH1B antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 29, 25 kDa | Observed band size: 29 kDa
| Cat.No | ADC-00837A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | APH1B |
| Target Synonyms | APH1B; PSFL; UNQ688/PRO1328; Gamma-secretase subunit APH-1B; APH-1b; Aph-1beta; Presenilin-stabilization factor-like | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Peptide sequence from Human Gamma-secretase subunit APH-1B protein (93-110AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8WW43 |
Uniprot Id
Q8WW43
Target Species
Human
Target Name
APH1B
Target Full Name
Gamma-secretase subunit APH-1B
Target Function
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
APH-1 family
Target Tissue Specificity
Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain.
Target Synonyms
APH1B; PSFL; UNQ688/PRO1328; Gamma-secretase subunit APH-1B; APH-1b; Aph-1beta; Presenilin-stabilization factor-like
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