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The antibody against ATP6V0A2 was raised in rabbit using the Recombinant Human V-type proton ATPase 116 kDa subunit a isoform 2 protein (476-549AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against ATP6V0A2 was raised in rabbit using the Recombinant Human V-type proton ATPase 116 kDa subunit a isoform 2 protein (476-549AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
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Immunofluorescent analysis of A431 cells using ATP6V0A2 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
| Cat.No | ADC-17634A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ATP6V0A2 |
| Target Synonyms | a2 antibody; A2V ATPase antibody; ARCL antibody; ATP6a2 antibody; ATP6N1D antibody; ATP6V0A2 antibody; ATPase, H+ transporting, lysosomal V0 subunit a isoform 2 antibody; ATPase | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human V-type proton ATPase 116 kDa subunit a isoform 2 protein (476-549AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y487 |
Uniprot Id
Q9Y487
Target Species
Human
Target Name
ATP6V0A2
Target Full Name
V-type proton ATPase 116 kDa subunit a 2
Target Function
Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation.
Target Involvement
Cutis laxa, autosomal recessive, 2A (ARCL2A); Wrinkly skin syndrome (WSS)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Endosome membrane.
Target Protein Families
V-ATPase 116 kDa subunit family
Target Synonyms
a2; A2V ATPase; ARCL; ATP6a2; ATP6N1D; ATP6V0A2; ATPase, H+ transporting, lysosomal V0 subunit a isoform 2; ATPase, H+ transporting, lysosomal V0 subunit a2; Infantile malignant osteopetrosis; J6B7; Lysosomal H(+) transporting ATPase V0 subunit a2; Lysosomal H(+)-transporting ATPase V0 subunit a2; regeneration and tolerance factor; Stv1; TJ6; TJ6M; TJ6s; V ATPase 116 kDa isoform a2; V type proton ATPase 116 kDa subunit a; V type proton ATPase 116 kDa subunit a isoform 2; V-ATPase 116 kDa isoform a2; V-type proton ATPase 116 kDa subunit a isoform 2; Vacuolar proton translocating ATPase 116 kDa subunit a; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2; Vph1; VPP2_HUMAN; WSS
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