Rabbit anti-Human Bak Polyclonal Antibody

The antibody against Bak was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human Bak (NP_001179.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-07770A

Number

Cat.No	ADA-07770A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	Bak
Target Synonyms	BAK; CDN1; BCL2L7; BAK-LIKE; Bak	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	MCF7, Mouse skeletal muscle, THP-1	Application	ELISA, WB

Cat.No

ADA-07770A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

Bak

Target Synonyms

BAK; CDN1; BCL2L7; BAK-LIKE; Bak

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

MCF7, Mouse skeletal muscle, THP-1

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Bak (NP_001179.1).	Target Species	Human
Immunogen Sequence	MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHL	Uniprot ID	Q16611

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Bak (NP_001179.1).

Target Species

Human

Immunogen Sequence

MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHL

Uniprot ID

Q16611

Background Information

Uniprot Id

Q16611
Target Species

Human
Target Name

BAK1
Target Full Name

Bcl-2 homologous antagonist/killer
Target Function

Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.
Target Subcellular Location

Mitochondrion outer membrane; Single-pass membrane protein.
Target Protein Families

Bcl-2 family
Target Tissue Specificity

Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
Target Synonyms

BAK1; BAK; BCL2L7; CDN1; Bcl-2 homologous antagonist/killer; Apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7
Target Background

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.

Rabbit anti-Human Bak Polyclonal Antibody

Specifications

Immunogen Information

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