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The antibody against BAMBI was raised in rabbit using the Recombinant Human BMP and activin membrane-bound inhibitor homolog protein (21-152AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against BAMBI was raised in rabbit using the Recombinant Human BMP and activin membrane-bound inhibitor homolog protein (21-152AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human prostate tissue using BAMBI Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon tissue using BAMBI Antibody at dilution of 1:1002
Immunohistochemistry of paraffin-embedded human placenta tissue using BAMBI Antibody at dilution of 1:1003
| Cat.No | ADC-44489A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BAMBI |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human BMP and activin membrane-bound inhibitor homolog protein (21-152AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q13145 |
Uniprot Id
Q13145
Target Species
Human
Target Name
BAMBI
Target Full Name
BMP and activin membrane-bound inhibitor homolog
Target Function
Negatively regulates TGF-beta signaling.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
BAMBI family
Target Tissue Specificity
High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.
Target Synonyms
BAMBI; BAMBI_HUMAN; BMP and activin membrane bound inhibitor homolog; BMP and activin membrane-bound inhibitor homolog; NMA; Non metastatic gene A protein; Non-metastatic gene A protein; Putative transmembrane protein NMA
Target Background
This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.
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