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The antibody against BCAT1 was raised in rabbit using the Recombinant Human Branched-chain-amino-acid aminotransferase, cytosolic protein (4-276AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against BCAT1 was raised in rabbit using the Recombinant Human Branched-chain-amino-acid aminotransferase, cytosolic protein (4-276AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry analysis of human melanoma using BCAT1 Antibody at dilution of 1:100
Immunohistochemistry analysis of human bladder cancer using BCAT1 Antibody at dilution of 1:1002
Immunofluorescent analysis of HepG2 cells using BCAT1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-22209A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BCAT1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Branched-chain-amino-acid aminotransferase, cytosolic protein (4-276AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P54687 |
Uniprot Id
P54687
Target Species
Human
Target Name
BCAT1
Target Full Name
Branched-chain-amino-acid aminotransferase, cytosolic
Target Function
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Class-IV pyridoxal-phosphate-dependent aminotransferase family
Target Tissue Specificity
During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.
Target Synonyms
BCAT ; BCAT(c); Bcat1; BCAT1_HUMAN; BCT1 ; Branched chain amino acid aminotransferase; cytosolic ; branched chain amino-acid transaminase 1; cytosolic; branched chain aminotransferase 1; branched chain aminotransferase 1; cytosolic; Branched-chain-amino-acid aminotransferase; cytosolic; DKFZp686E12175 ; EC 2.6.1.42; ECA39 ; MECA39 ; placental protein 18; PNAS 121 ; PP18; Protein ECA39
Target Background
This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.
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