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The antibody against BCKDK was raised in rabbit using the Synthesized peptide derived from Internal of Human BCKD. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IF.
The antibody against BCKDK was raised in rabbit using the Synthesized peptide derived from Internal of Human BCKD. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IF.
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Western blot analysis of extracts from 293 cells and Jurkat cells, using BCKD antibody.
Immunofluorescence analysis of HeLa cells, using BCKD antibody.2
| Cat.No | ADC-42243A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BCKDK |
| Target Synonyms | [3 methyl 2 oxobutanoate dehydrogenase [lipoamide]] kinase | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from Internal of Human BCKD. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O14874 |
Uniprot Id
O14874
Target Species
Human
Target Name
BCKDK
Target Full Name
Branched-chain alpha-ketoacid dehydrogenase kinase
Target Function
Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
Target Involvement
Branched-chain ketoacid dehydrogenase kinase deficiency (BCKDKD)
Target Subcellular Location
Mitochondrion matrix. Mitochondrion.
Target Protein Families
PDK/BCKDK protein kinase family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
[3 methyl 2 oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial ; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase; BCKD kinase ; BCKD-kinase; BCKD_HUMAN; BCKDHKIN; Bckdk; BCKDKD; BDK; Branched chain alpha keto acid dehydrogenase kinase; Branched chain ketoacid dehydrogenase kinase; Branched-chain alpha-ketoacid dehydrogenase kinase; mitochondrial
Target Background
The branched-chain alpha-ketoacid dehydrogenase complex (BCKD) is an important regulator of the valine, leucine, and isoleucine catabolic pathways. The protein encoded by this gene is found in the mitochondrion, where it phosphorylates and inactivates BCKD. Several transcript variants encoding different isoforms have been found for this gene.
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