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The antibody against BEX2 was raised in rabbit using the Recombinant Human Protein BEX2 protein (1-128AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against BEX2 was raised in rabbit using the Recombinant Human Protein BEX2 protein (1-128AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human thyroid tissue using BEX2 Antibody at dilution of 1:100
| Cat.No | ADC-25212A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BEX2 |
| Target Synonyms | BEX2Protein BEX2 antibody; Brain-expressed X-linked protein 2 antibody; hBex2 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein BEX2 protein (1-128AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BXY8 |
Uniprot Id
Q9BXY8
Target Species
Human
Target Name
BEX2
Target Full Name
Protein BEX2
Target Function
Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
BEX family
Target Tissue Specificity
Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Widely expressed in breast cancer cell lines.
Target Synonyms
BEX2Protein BEX2; Brain-expressed X-linked protein 2; hBex2
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