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The antibody against BMP8A was raised in rabbit using the Synthesized peptide derived from C-terminal of Human BMP8A. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IF.
The antibody against BMP8A was raised in rabbit using the Synthesized peptide derived from C-terminal of Human BMP8A. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IF.
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Western blot analysis of extracts from COLO cells, using BMP8A antibody.
Immunofluorescence analysis of A549 cells, using BMP8A antibody.2
| Cat.No | ADC-41409A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BMP8A |
| Target Synonyms | BMP-8A antibody; BMP8 antibody; Bmp8a antibody; BMP8A_HUMAN antibody; Bone morphogenetic protein 8A antibody; FLJ14351 antibody; FLJ45264 antibody; OP 2 antibody; Osteogenic protein 2 antibody | Form | Liquid |
| Species Reactivity | Human | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from C-terminal of Human BMP8A. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7Z5Y6 |
Uniprot Id
Q7Z5Y6
Target Species
Human
Target Name
BMP8A
Target Full Name
Bone morphogenetic protein 8A
Target Function
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.; Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway.
Target Subcellular Location
Secreted.
Target Protein Families
TGF-beta family
Target Synonyms
BMP-8A; BMP8; Bmp8a; BMP8A_HUMAN; Bone morphogenetic protein 8A; FLJ14351; FLJ45264; OP 2; Osteogenic protein 2
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