Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The antibody against BRAP was raised in rabbit using the Recombinant Human BRCA1-associated protein (13-124AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against BRAP was raised in rabbit using the Recombinant Human BRCA1-associated protein (13-124AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
$299.00
Western Blot Positive WB detected in: Mouse Brain tissue lysate, Mouse Heart tissue lysate, Rat Heart tissue lysate, All lanes: BRAP antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 68 kDa Observed band size: 68 kDa
Western Blot Positive WB detected in: K562 whole cell lysate, A549 whole cell lysate, 293T whole cell lysate, JK whole cell lysate, MCF7 whole cell lysate All lanes: BRAP antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 68 kDa Observed band size: 68 kDa2
| Cat.No | ADC-05640A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BRAP |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human BRCA1-associated protein (13-124AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7Z569 |
Uniprot Id
Q7Z569
Target Species
Human
Target Name
BRAP
Target Full Name
BRCA1-associated protein
Target Function
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Target Subcellular Location
Cytoplasm.
Target Tissue Specificity
Expressed in breast epithelial cell lines.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
BRAP; RNF52BRCA1-associated protein; EC 2.3.2.27; BRAP2; Impedes mitogenic signal propagation; IMP; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2; Renal carcinoma antigen NY-REN-63
Target Background
The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
