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The antibody against INAVA was raised in rabbit using the Human C1orf106 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against INAVA was raised in rabbit using the Human C1orf106 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$600.00
| Cat.No | ADC-49099A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | INAVA |
| Target Synonyms | C1orf106 antibody; CA106_HUMAN antibody; Chromosome 1 open reading frame 106 antibody; FLJ10901 antibody; Uncharacterized protein C1orf106 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.02% sodium azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Human C1orf106 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q3KP66 |
Uniprot Id
Q3KP66
Target Species
Human
Target Name
INAVA
Target Full Name
Innate immunity activator protein
Target Function
Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Tissue Specificity
Highly expressed in intestinal myeloid-derived cells and expressed in monocyte-derived macrophages upon induction by PRR activation.
Target Research Area
Cell Biology
Target Synonyms
C1orf106; CA106_HUMAN; Chromosome 1 open reading frame 106 ; FLJ10901; Uncharacterized protein C1orf106
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