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Rabbit anti-Human CA5A Polyclonal Antibody

The antibody against CA5A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 39-305 of human CA5A (NP_001730.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-05497A

The antibody against CA5A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 39-305 of human CA5A (NP_001730.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

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Specifications


Cat.No ADA-05497A ClonalityPolyclonal
Host SpeciesRabbitTarget NameCA5A
Target SynonymsCA5; CAV; CAVA; CA5AD; GS1-21A4.1; CA5AFormLiquid
Species ReactivityHuman, Mouse, RatIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.01% thimerosal, pH7.3.Purification MethodAffinity purification
Positive SamplesMouse liverApplicationELISA, WB, IF/ICC

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 39-305 of human CA5A (NP_001730.1).Target SpeciesHuman
Uniprot IDP35218Immunogen Sequence
Background Information
  • Uniprot Id

    P35218

  • Target Species

    Human

  • Target Name

    CA5A

  • Target Full Name

    Carbonic anhydrase 5A, mitochondrial

  • Target Function

    Reversible hydration of carbon dioxide. Low activity.

  • Target Involvement

    Hyperammonemia due to carbonic anhydrase VA deficiency (CA5AD)

  • Target Subcellular Location

    Mitochondrion.

  • Target Protein Families

    Alpha-carbonic anhydrase family

  • Target Research Area

    Metabolism

  • Target Synonyms

    CA5A; CA5Carbonic anhydrase 5A; mitochondrial; EC 4.2.1.1; Carbonate dehydratase VA; Carbonic anhydrase VA; CA-VA

  • Target Background

    Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2.

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