Rabbit anti-Human CACNA1D Polyclonal Antibody

Uniprot Id

Q01668

Target Species

Human

Target Name

CACNA1D

Target Full Name

Voltage-dependent L-type calcium channel subunit alpha-1D

Target Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines.

Target Involvement

Sinoatrial node dysfunction and deafness (SANDD); Primary aldosteronism, seizures, and neurologic abnormalities (PASNA)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1D subfamily

Target Tissue Specificity

Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle.

Target Synonyms

alpha-1 polypeptide; CAC1D_HUMAN; CACH3; CACN4; CACNA 1D; Cacna1d; CACNL1A2; Calcium channel; Calcium channel L type alpha 1 polypeptide isoform 2; Calcium channel neuroendocrine/brain type alpha 1 subunit; Calcium channel voltage dependent L type alpha 1; Calcium channel voltage dependent L type alpha 1D subunit; Cav1.3; CCHL1A2; isoform 2; L type; PASNA; SANDD; Voltage dependent L type calcium channel subunit alpha 1D; Voltage gated calcium channel alpha 1 subunit; Voltage gated calcium channel alpha subunit Cav1.3; Voltage gated calcium channel subunit alpha Cav1.3; Voltage-dependent L-type calcium channel subunit alpha-1D; Voltage-gated calcium channel subunit alpha Cav1.3

Target Background

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.