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The antibody against CAPN3 was raised in rabbit using the Recombinant Human Calpain-3 protein (582-821AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against CAPN3 was raised in rabbit using the Recombinant Human Calpain-3 protein (582-821AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$299.00
| Cat.No | ADC-44972A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CAPN3 |
| Target Synonyms | (p94) antibody; Calpain L3 antibody; Calpain large polypeptide L3 antibody; Calpain p94 antibody; calpain p94, Calcium-activated neutral proteinase 3 antibody; calpain 3, large [catalytic] subunit antibody; calpain | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Calpain-3 protein (582-821AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P20807 |
Uniprot Id
P20807
Target Species
Human
Target Name
CAPN3
Target Full Name
Calpain-3
Target Function
Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53.
Target Involvement
Limb-girdle muscular dystrophy 2A (LGMD2A)
Target Subcellular Location
Cytoplasm. Nucleus, nucleolus.
Target Protein Families
Peptidase C2 family
Target Tissue Specificity
Isoform I is skeletal muscle specific.
Target Research Area
Cell Biology
Target Synonyms
Calcium-activated neutral proteinase 3; calpain 3, (p94); Calpain L3; Calpain large polypeptide L3 ; Calpain p94; calpain p94, large [catalytic] subunit; calpain, large polypeptide L3; Calpain-3; CAN3_HUMAN; CANP 3; CANP3; CANPL3; CAPN3; LGMD 2A; LGMD2; LGMD2A; Lp82; Lp85; MGC10767; MGC11121; MGC14344; MGC4403; Muscle-specific calcium-activated neutral protease 3; muscle-specific calcium-activated neutral protease 3 large subunit; nCL-1; New calpain 1; p94
Target Background
Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.
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