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The antibody against CARD14 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human CARD14 (NP_001244899.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against CARD14 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human CARD14 (NP_001244899.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-00161A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CARD14 |
| Target Synonyms | PRP; PSS1; BIMP2; CARMA2; PSORS2; CARD14 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, HT-29 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human CARD14 (NP_001244899.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BXL6 | Immunogen Sequence |
Uniprot Id
Q9BXL6
Target Species
Human
Target Name
CARD14
Target Full Name
Caspase recruitment domain-containing protein 14
Target Function
Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.; Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator.
Target Involvement
Psoriasis 2 (PSORS2); Pityriasis rubra pilaris (PRP)
Target Subcellular Location
[Isoform 1]: Cytoplasm.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm.
Target Tissue Specificity
Isoform 1 is detected in placenta and epidermal keratinocytes. Isoform 2 is detected in leukocytes and fetal brain.
Target Synonyms
Bcl10 interacting MAGUK protein 2; Bimp 2; Bimp2 ; CAR14_HUMAN; CARD 14; CARD containing MAGUK 2 protein; CARD containing MAGUK protein 2; Card maguk protein 2; CARD-containing MAGUK protein 2; CARD14; Carma 2; Carma2; Caspase recruitment domain containing protein 14; Caspase recruitment domain family member 14; Caspase recruitment domain protein 14; Caspase recruitment domain-containing protein 14; PRP; PSORS2; PSS1
Target Background
This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants.
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