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The antibody against CARMIL2 was raised in rabbit using the Recombinant Human Capping protein, Arp2/3 and myosin-I linker protein 2 protein (1136-1290AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IP.
The antibody against CARMIL2 was raised in rabbit using the Recombinant Human Capping protein, Arp2/3 and myosin-I linker protein 2 protein (1136-1290AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IP.
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Western Blot | Positive WB detected in: Jurkat whole cell lysate | All lanes: CARMIL2 antibody at 1:1000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 155, 149 kDa | Observed band size: 155 kDa
| Cat.No | ADC-02063A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CARMIL2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB, IP | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Capping protein, Arp2/3 and myosin-I linker protein 2 protein (1136-1290AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6F5E8 |
Uniprot Id
Q6F5E8
Target Species
Human
Target Name
CARMIL2
Target Full Name
Capping protein, Arp2/3 and myosin-I linker protein 2
Target Function
Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization. Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations. Involved as well in cell migration and invadopodia formation during wound healing. Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells.
Target Subcellular Location
[Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, ruffle.
Target Protein Families
CARMIL family
Target Tissue Specificity
Expressed in all tissues tested, including thymus, spleen, colon, leukocytes, peripheral blood, skin, skin keratinocytes and skin fibroblasts. Strong expression is detected in naive and memory CD4+ and CD8+ T cells, naive and memory B cells, regulatory T
Target Synonyms
CARMIL2; CARMIL2b; Leucine rich repeat containing 16C; leucine-rich repeat; Leucine-rich repeat-containing protein 16C; LR16C_HUMAN; LRRC16C; RGD; RGD leucine rich repeat tropomodulin and proline rich containing protein; RGD motif leucine rich repeats tropomodulin domain and proline rich containing; Rltpr; tropomodulin and proline-rich-containing protein
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