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The antibody against CDH4 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human R-cadherin. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, IF, ELISA.
The antibody against CDH4 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human R-cadherin. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, IF, ELISA.
$167.00
| Cat.No | ADC-33039A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CDH4 |
| Target Synonyms | CDH4; Cadherin-4; Retinal cadherin; R-CAD; R-cadherin | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the C-terminal region of Human R-cadherin. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P55283 |
Uniprot Id
P55283
Target Species
Human
Target Name
CDH4
Target Full Name
Cadherin-4
Target Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Tissue Specificity
Expressed mainly in brain but also found in other tissues.
Target Synonyms
CDH4; Cadherin-4; Retinal cadherin; R-CAD; R-cadherin
Target Background
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.
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