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The antibody against CDK10 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Cdk10. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
The antibody against CDK10 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Cdk10. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
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Western Blot analysis of 293 cells using Cdk10 Polyclonal Antibody
Western Blot analysis of RAT-Intestine cells using Cdk10 Polyclonal Antibody2
| Cat.No | ADC-39060A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CDK10 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human Cdk10. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15131 |
Uniprot Id
Q15131
Target Species
Human
Target Name
CDK10
Target Full Name
Cyclin-dependent kinase 10
Target Function
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.
Target Involvement
Al Kaissi syndrome (ALKAS)
Target Subcellular Location
Cytoplasm, cytoskeleton, cilium basal body.
Target Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Target Synonyms
CDC2 related protein kinase; Cdk10; CDK10_HUMAN; Cell division protein kinase 10; Cyclin dependent kinase 10; Cyclin dependent kinase related protein; Cyclin-dependent kinase 10; PISSLRE; Serine/threonine protein kinase PISSLRE; Serine/threonine-protein kinase PISSLRE
Target Background
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene.
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