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The antibody against CHD4 was raised in rabbit using the Synthesized peptide derived from internal of Human CHD4. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, IHC, IF.
The antibody against CHD4 was raised in rabbit using the Synthesized peptide derived from internal of Human CHD4. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, IHC, IF.
$297.00
Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using CHD4 antibody.
Immunofluorescence analysis of HepG2 cells, using CHD4 antibody.2
| Cat.No | ADC-41964A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CHD4 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human CHD4. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14839 |
Uniprot Id
Q14839
Target Species
Human
Target Name
CHD4
Target Full Name
Chromodomain-helicase-DNA-binding protein 4
Target Function
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.
Target Involvement
Sifrim-Hitz-Weiss syndrome (SIHIWES)
Target Subcellular Location
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Protein Families
SNF2/RAD54 helicase family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
ATP dependent helicase CHD4; ATP-dependent helicase CHD4; CHD 4; CHD-4; CHD4; CHD4_HUMAN; Chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4; Mi 2 autoantigen 218 kDa protein; Mi 2b; Mi-2 autoantigen 218 kDa protein; Mi2 beta; Mi2-beta
Target Background
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms.
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