Rabbit anti-Human CHST11 Polyclonal Antibody

Uniprot Id

Q9NPF2

Target Species

Human

Target Name

CHST11

Target Full Name

Carbohydrate sulfotransferase 11

Target Function

Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.

Target Involvement

A chromosomal aberration involving CHST11 is found in B-cell chronic lymphocytic leukemias. Translocation t(12;14)(q23;q32) with IgH.

Target Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Target Protein Families

Sulfotransferase 2 family

Target Tissue Specificity

Widely expressed. Highly expressed in spleen, thymus, bone marrow, peripheral blood leukocytes, lymph node, heart, brain, lung and placenta.

Target Synonyms

C4S-1; C4ST 1; C4ST; C4ST-1; C4ST1; Carbohydrate (chondroitin 4) sulfotransferase 11; Carbohydrate sulfotransferase 11; Chondroitin 4 O sulfotransferase 1; Chondroitin 4 sulfotransferase; Chondroitin 4-O-sulfotransferase 1; Chondroitin 4-sulfotransferase 1; CHST 11; Chst11; CHSTB_HUMAN; HSA269537; IgH/CHST11 fusion

Target Background

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.