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The antibody against CIR1 was raised in rabbit using the Recombinant Human Corepressor interacting with RBPJ 1 protein (1-160AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against CIR1 was raised in rabbit using the Recombinant Human Corepressor interacting with RBPJ 1 protein (1-160AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human lung tissue using CIR1 Antibody at dilution of 1:1002
| Cat.No | ADC-16512A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CIR1 |
| Target Synonyms | CIR1 antibody; CIRCorepressor interacting with RBPJ 1 antibody; CBF1-interacting corepressor antibody; Recepin antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Corepressor interacting with RBPJ 1 protein (1-160AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q86X95 |
Uniprot Id
Q86X95
Target Species
Human
Target Name
CIR1
Target Full Name
Corepressor interacting with RBPJ 1
Target Function
May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
Target Subcellular Location
Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome.
Target Tissue Specificity
Highly expressed in heart, brain, placenta, liver, skeletal muscle and pancreas.
Target Synonyms
CIR1; CIRCorepressor interacting with RBPJ 1; CBF1-interacting corepressor; Recepin
Target Background
Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of protein-containing complex. Colocalizes with centrosome.
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