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The antibody against CIRBP was raised in rabbit using the Recombinant Human Cold-inducible RNA-binding protein (1-172AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA.
The antibody against CIRBP was raised in rabbit using the Recombinant Human Cold-inducible RNA-binding protein (1-172AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-40407A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CIRBP |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Cold-inducible RNA-binding protein (1-172AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14011 |
Uniprot Id
Q14011
Target Species
Human
Target Name
CIRBP
Target Full Name
Cold-inducible RNA-binding protein
Target Function
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed.
Target Subcellular Location
Nucleus, nucleoplasm. Cytoplasm.
Target Tissue Specificity
Ubiquitous.
Target Research Area
Cell Biology, Epigenetics and Nuclear Signaling
Target Synonyms
A18 hnRNP; A18HNRNP; cirbp; CIRBP_HUMAN; CIRP; Cold inducible RNA binding protein; Cold-inducible RNA-binding protein; Glycine rich RNA binding protein; Glycine-rich RNA-binding protein CIRP; testicular tissue protein Li 39
Target Background
Enables mRNA 3'-UTR binding activity and small ribosomal subunit rRNA binding activity. Involved in mRNA stabilization; positive regulation of translation; and response to UV. Located in cytoplasm and nucleoplasm.
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