Rabbit anti-Human CLEC10A Polyclonal Antibody

Uniprot Id

Q8IUN9

Target Species

Human

Target Name

CLEC10A

Target Full Name

C-type lectin domain family 10 member A

Target Function

Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells.

Target Subcellular Location

Membrane; Single-pass type II membrane protein.

Target Synonyms

C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 13 (macrophage derived); C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 14 (macrophage derived); C type lectin domain family 10; member A; C type lectin superfamily member 14; C-type lectin domain family 10 member A; C-type lectin superfamily member 14; CD301; CD301 antigen; CD301A; CLC10_HUMAN; CLEC10A; CLECSF13; CLECSF14; HML; HML2; Lectin; Macrophage C type lectin; MACROPHAGE GALACTOSE-TYPE C-TYPE; Macrophage lectin 2 (calcium dependent); Macrophage lectin 2; MGL; Mgl1

Target Background

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell surface antigen. Two transcript variants encoding distinct isoforms have been identified for this gene.