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The antibody against CNGA1 was raised in rabbit using the Synthesized peptide derived from internal of Human CNGA1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against CNGA1 was raised in rabbit using the Synthesized peptide derived from internal of Human CNGA1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from HepG2 cells and K562 cells, using CNGA1 antibody.
| Cat.No | ADC-41335A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CNGA1 |
| Target Synonyms | photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha | Form | Liquid |
| Species Reactivity | Human | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human CNGA1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P29973 |
Uniprot Id
P29973
Target Species
Human
Target Name
CNGA1
Target Full Name
Cyclic nucleotide-gated channel alpha-1
Target Function
Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.
Target Involvement
Retinitis pigmentosa 49 (RP49)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family, CNGA1 subfamily
Target Tissue Specificity
Rod cells in the retina.
Target Synonyms
CNGA1; CNCG; CNCG1; cGMP-gated cation channel alpha-1; Cyclic nucleotide-gated cation channel 1; Cyclic nucleotide-gated channel alpha-1; CNG channel alpha-1; CNG-1; CNG1; Cyclic nucleotide-gated channel, photoreceptor; Rod photoreceptor cGMP-gated channel subunit alpha
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