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The antibody against CNOT3 was raised in rabbit using the Recombinant Human CCR4-NOT transcription complex subunit 3 protein (257-395AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against CNOT3 was raised in rabbit using the Recombinant Human CCR4-NOT transcription complex subunit 3 protein (257-395AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-08048A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CNOT3 |
| Target Synonyms | homolog of antibody; NOT3 (negative regulator of transcription 3, S. cerevisiae, yeast) homolog antibody; NOT3 antibody; NOT3H antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human CCR4-NOT transcription complex subunit 3 protein (257-395AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O75175 |
Uniprot Id
O75175
Target Species
Human
Target Name
CNOT3
Target Full Name
CCR4-NOT transcription complex subunit 3
Target Function
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
Target Subcellular Location
Cytoplasm. Nucleus. Cytoplasm, P-body.
Target Protein Families
CNOT2/3/5 family
Target Tissue Specificity
Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes.
Target Synonyms
CCR4 associated factor 3; CCR4-associated factor 3; CCR4-NOT transcription complex subunit 3; CNOT3; CNOT3_HUMAN; KIAA0691; LENG2; Leukocyte receptor cluster member 2; negative regulator of transcription 3, S. cerevisiae, homolog of; NOT3 (negative regulator of transcription 3, yeast) homolog; NOT3; NOT3H
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