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The antibody against COLQ was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 276-455 of human COLQ (NP_005668.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against COLQ was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 276-455 of human COLQ (NP_005668.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01531A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | COLQ |
| Target Synonyms | EAD; CMS5; COLQ | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat heart, Mouse lung, Mouse skeletal muscle, Rat skeletal muscle, Rat testis | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 276-455 of human COLQ (NP_005668.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGSDFGYLTCETYLPGSYGDLQCTQYCYIDSTPCRYFT | Uniprot ID | Q9Y215 |
Uniprot Id
Q9Y215
Target Species
Human
Target Name
COLQ
Target Full Name
Acetylcholinesterase collagenic tail peptide
Target Function
Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.
Target Involvement
Myasthenic syndrome, congenital, 5 (CMS5)
Target Subcellular Location
Cell junction, synapse.
Target Protein Families
COLQ family
Target Tissue Specificity
Found at the end plate of skeletal muscle.
Target Synonyms
Acetylcholinesterase collagen-like tail subunit isoform I; Acetylcholinesterase collagenic tail peptide; Acetylcholinesterase collagenic tail peptide precursor; Acetylcholinesterase-associated collagen; AChE Q subunit; asymmetric acetylcholinesterase; Collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase ; Colq; COLQ_HUMAN; EAD; OTTHUMP00000209566; OTTHUMP00000209567; single strand of homotrimeric collagen-like tail subunit of asymmetric acetylcholinesterase
Target Background
This gene encodes the subunit of a collagen-like molecule associated with acetylcholinesterase in skeletal muscle. Each molecule is composed of three identical subunits. Each subunit contains a proline-rich attachment domain (PRAD) that binds an acetylcholinesterase tetramer to anchor the catalytic subunit of the enzyme to the basal lamina. Mutations in this gene are associated with endplate acetylcholinesterase deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.
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