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Rabbit anti-Human COLQ Polyclonal Antibody

The antibody against COLQ was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 276-455 of human COLQ (NP_005668.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01531A

The antibody against COLQ was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 276-455 of human COLQ (NP_005668.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-01531A ClonalityPolyclonal
Host SpeciesRabbitTarget NameCOLQ
Target SynonymsEAD; CMS5; COLQFormLiquid
Species ReactivityMouse, RatIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.02% sodium azide, pH7.3.Purification MethodAffinity purification
Positive SamplesRat heart, Mouse lung, Mouse skeletal muscle, Rat skeletal muscle, Rat testisApplicationELISA, WB

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 276-455 of human COLQ (NP_005668.2).Target SpeciesHuman
Immunogen SequenceMGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGSDFGYLTCETYLPGSYGDLQCTQYCYIDSTPCRYFTUniprot IDQ9Y215
Background Information
  • Uniprot Id

    Q9Y215

  • Target Species

    Human

  • Target Name

    COLQ

  • Target Full Name

    Acetylcholinesterase collagenic tail peptide

  • Target Function

    Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.

  • Target Involvement

    Myasthenic syndrome, congenital, 5 (CMS5)

  • Target Subcellular Location

    Cell junction, synapse.

  • Target Protein Families

    COLQ family

  • Target Tissue Specificity

    Found at the end plate of skeletal muscle.

  • Target Synonyms

    Acetylcholinesterase collagen-like tail subunit isoform I; Acetylcholinesterase collagenic tail peptide; Acetylcholinesterase collagenic tail peptide precursor; Acetylcholinesterase-associated collagen; AChE Q subunit; asymmetric acetylcholinesterase; Collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase ; Colq; COLQ_HUMAN; EAD; OTTHUMP00000209566; OTTHUMP00000209567; single strand of homotrimeric collagen-like tail subunit of asymmetric acetylcholinesterase

  • Target Background

    This gene encodes the subunit of a collagen-like molecule associated with acetylcholinesterase in skeletal muscle. Each molecule is composed of three identical subunits. Each subunit contains a proline-rich attachment domain (PRAD) that binds an acetylcholinesterase tetramer to anchor the catalytic subunit of the enzyme to the basal lamina. Mutations in this gene are associated with endplate acetylcholinesterase deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.

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