Rabbit anti-Human COX15 Polyclonal Antibody

Uniprot Id

Q7KZN9

Target Species

Human

Target Name

COX15

Target Full Name

Heme A synthase COX15

Target Function

May be involved in the biosynthesis of heme A.

Target Involvement

Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 2 (CEMCOX2); Leigh syndrome (LS)

Target Subcellular Location

Mitochondrion membrane; Multi-pass membrane protein.

Target Protein Families

COX15/CtaA family

Target Tissue Specificity

Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.

Target Synonyms

CEMCOX2; COX15; COX15 homolog; cytochrome c oxidase assembly protein; COX15; S. cerevisiae; homolog of; COX15_HUMAN; cytochrome c oxidase assembly homolog 15 (yeast); Cytochrome c oxidase assembly protein COX15 homolog; cytochrome c oxidase subunit 15

Target Background

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region.