Rabbit anti-Human CYP7A1 Polyclonal Antibody

Uniprot Id

P22680

Target Species

Human

Target Name

CYP7A1

Target Full Name

Cytochrome P450 7A1

Target Function

A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis. 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol. Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives.

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Target Protein Families

Cytochrome P450 family

Target Tissue Specificity

Detected in liver.

Target Research Area

Cancer

Target Synonyms

Cholesterol 7 alpha hydroxylase; Cholesterol 7 alpha monooxygenase; Cholesterol 7-alpha-hydroxylase; Cholesterol 7-alpha-monooxygenase; CP7A; CP7A1_HUMAN; CYP 7; CYP7; CYP7A1; CYPVII; Cytochrome P450 7A1; Cytochrome P450; family 7; subfamily A; polypeptide 1; Cytochrome P450; subfamily VIIA (cholesterol 7 alpha monooxygenase),; Cytochrome P450; subfamily VIIA (cholesterol 7 alpha-monooxygenase); polypeptide 1; MGC126826; MGC138389

Target Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis.