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The antibody against CYREN was raised in rabbit using the Recombinant Human Cell cycle regulator of non-homologous end joining protein (1-157AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
The antibody against CYREN was raised in rabbit using the Recombinant Human Cell cycle regulator of non-homologous end joining protein (1-157AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
$299.00
| Cat.No | ADC-14932A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CYREN |
| Target Synonyms | C7orf49 antibody; Chromosome 7 open reading frame 49 antibody; Modulator of retrovirus infection homolog antibody; MRI antibody; MRI_HUMAN antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | FITC conjugated | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Cell cycle regulator of non-homologous end joining protein (1-157AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BWK5 |
Uniprot Id
Q9BWK5
Target Species
Human
Target Name
CYREN
Target Full Name
Cell cycle regulator of non-homologous end joining
Target Function
Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase. Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present. Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination. Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70. In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin. Also involved in immunoglobulin V(D)J recombination. May also act as an indirect regulator of proteasome.
Target Subcellular Location
[Isoform 1]: Cytoplasm. Nucleus. Chromosome.; [Isoform 3]: Cytoplasm.; [Isoform 4]: Cytoplasm. Nucleus.
Target Synonyms
C7orf49; Chromosome 7 open reading frame 49; Modulator of retrovirus infection homolog; MRI; MRI_HUMAN
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