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The antibody against DAB1 was raised in rabbit using the Peptide sequence around aa.230~234 (G-V-Y-D-V) derived from Human Dab1. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. This antibody has been validated on ELISA, IHC.
The antibody against DAB1 was raised in rabbit using the Peptide sequence around aa.230~234 (G-V-Y-D-V) derived from Human Dab1. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. This antibody has been validated on ELISA, IHC.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Dab1(Ab-232) Antibody(left) or the same antibody preincubated with blocking peptide(right).
| Cat.No | ADC-43353A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DAB1 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Peptide sequence around aa.230~234 (G-V-Y-D-V) derived from Human Dab1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O75553 |
Uniprot Id
O75553
Target Species
Human
Target Name
DAB1
Target Full Name
Disabled homolog 1
Target Function
Adapter molecule functioning in neural development. May regulate SIAH1 activity.
Target Involvement
Spinocerebellar ataxia 37 (SCA37)
Target Tissue Specificity
Mainly expressed in brain.
Target Synonyms
Dab 1; Dab reelin signal transducer 1; Dab; reelin signal transducer; homolog 1 (Drosophila); Dab1; DAB1_HUMAN; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari
Target Background
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain.
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