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The antibody against DEDD2 was raised in rabbit using the Recombinant Human DNA-binding death effector domain-containing protein 2 protein (1-240AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against DEDD2 was raised in rabbit using the Recombinant Human DNA-binding death effector domain-containing protein 2 protein (1-240AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human kidney tissue using DEDD2 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human brain tissue using DEDD2 Antibody at dilution of 1:1002
| Cat.No | ADC-25342A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DEDD2 |
| Target Synonyms | DEDD2 antibody; FLAME3 antibody; PSEC0004DNA-binding death effector domain-containing protein 2 antibody; DED-containing protein FLAME-3 antibody; FADD-like anti-apoptotic molecule 3 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human DNA-binding death effector domain-containing protein 2 protein (1-240AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8WXF8 |
Uniprot Id
Q8WXF8
Target Species
Human
Target Name
DEDD2
Target Full Name
DNA-binding death effector domain-containing protein 2
Target Function
May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
Target Subcellular Location
Nucleus, nucleolus. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli.
Target Tissue Specificity
Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell l
Target Synonyms
DEDD2; FLAME3; PSEC0004DNA-binding death effector domain-containing protein 2; DED-containing protein FLAME-3; FADD-like anti-apoptotic molecule 3
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