Rabbit anti-Human Desmocollin 3 Polyclonal Antibody

The antibody against Desmocollin 3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 576-690 of human Desmocollin 3 (NP_001932.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-07994A

Number

Cat.No	ADA-07994A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	Desmocollin 3
Target Synonyms	DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP; Desmocollin 3	Form	Liquid
Species Reactivity	Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	Rat thymus	Application	ELISA, WB

Cat.No

ADA-07994A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

Desmocollin 3

Target Synonyms

DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP; Desmocollin 3

Form

Liquid

Species Reactivity

Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

Rat thymus

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 576-690 of human Desmocollin 3 (NP_001932.2).	Target Species	Human
Immunogen Sequence	EILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGK	Uniprot ID	Q14574

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 576-690 of human Desmocollin 3 (NP_001932.2).

Target Species

Human

Immunogen Sequence

EILQEYVVICKPKMGYTDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYTIPITVKDRAGQAATKLLRVNLCECTHPTQCRATSRSTGVILGK

Uniprot ID

Q14574

Background Information

Uniprot Id

Q14574
Target Species

Human
Target Name

DSC3
Target Full Name

Desmocollin-3
Target Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Target Involvement

Hypotrichosis and recurrent skin vesicles (HRSV)
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Target Tissue Specificity

Epidermis, buccal mucosa, esophagus and cervix.
Target Synonyms

Cadherin family member 3; CDHF3; desmocollin 3a/3b; Desmocollin 4; Desmocollin-3; Desmocollin-4; Desmocollin3; Desmocollin4; DSC; DSC1; DSC2; DSC3; DSC3_HUMAN; DSC4; HT CP; HT-CP; HTCP
Target Background

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants.

Rabbit anti-Human Desmocollin 3 Polyclonal Antibody

Specifications

Immunogen Information

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