Rabbit anti-Human DHX38 Polyclonal Antibody

Uniprot Id

Q92620

Target Species

Human

Target Name

DHX38

Target Full Name

Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

Target Function

Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome.

Target Subcellular Location

Nucleus.

Target Protein Families

DEAD box helicase family, DEAH subfamily, PRP16 sub-subfamily

Target Synonyms

ATP dependent RNA helicase DHX38; ATP-dependent RNA helicase DHX38; DDX38; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 38; DEAH (Asp-Glu-Ala-His) box polypeptide 38; DEAH box protein 38; DHX38; KIAA0224; Pre mRNA splicing factor ATP dependent RNA helicase PRP16; Pre-mRNA splicing factor 16 ; Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16; Prp16; PRP16 homolog of S.cerevisiae, pre-mRNA splicing factor ATP-dependent RNA helicase PRP16; PRP16_HUMAN; PRPF16

Target Background

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process.