Rabbit anti-Human DPF1 Polyclonal Antibody

Uniprot Id

Q92782

Target Species

Human

Target Name

DPF1

Target Full Name

Zinc finger protein neuro-d4

Target Function

May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

Requiem/DPF family

Target Synonyms

BAF45B; BRG1-associated factor 45B; D4; D4 zinc and double PHD fingers family 1; DPF1; DPF1_HUMAN; NEUD4; Neuro d4 homolog; Zinc and double PHD fingers family 1; Zinc finger protein neuro-d4