Rabbit anti-Human EDA Polyclonal Antibody

Uniprot Id

Q92838

Target Species

Human

Target Name

EDA

Target Full Name

Ectodysplasin-A

Target Function

Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. May also play a role in cell adhesion.; Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R.; Binds only to the receptor EDA2R.

Target Involvement

Ectodermal dysplasia 1, hypohidrotic, X-linked (XHED); Tooth agenesis, selective, X-linked, 1 (STHAGX1)

Target Subcellular Location

Cell membrane; Single-pass type II membrane protein.; [Ectodysplasin-A, secreted form]: Secreted.

Target Protein Families

Tumor necrosis factor family

Target Tissue Specificity

Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.

Target Synonyms

ECTD1; Ectodermal dysplasia 1; anhidrotic ; Ectodermal dysplasia protein; Ectodermal dysplasia; anhidrotic (hypohydrotic); Ectodysplasin A; Ectodysplasin A; membrane form; Ectodysplasin A; secreted form; ECTODYSPLASIN A1 ISOFORM; ECTODYSPLASIN A2 ISOFORM; ECTODYSPLASIN; Ectodysplasin-A; ED1 A1; ED1 A2; ED1; ED1 GENE; Eda A1; Eda A2 ; eda; EDA protein; EDA protein homolog; EDA_HUMAN; EDA1; EDA1 GENE; EDA2; HED; HED1; ODT1; Oligodontia 1; secreted form; STHAGX1; Ta; Tabby; Tabby protein ; X linked anhidroitic ectodermal dysplasia protein; XHED; XLHED

Target Background

The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.