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The antibody against EDEM2 was raised in rabbit using the Recombinant Human ER degradation-enhancing alpha-mannosidase-like protein 2 protein (22-300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against EDEM2 was raised in rabbit using the Recombinant Human ER degradation-enhancing alpha-mannosidase-like protein 2 protein (22-300AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human thyroid tissue using EDEM2 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon tissue using EDEM2 Antibody at dilution of 1:1002
| Cat.No | ADC-25013A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EDEM2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human ER degradation-enhancing alpha-mannosidase-like protein 2 protein (22-300AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BV94 |
Uniprot Id
Q9BV94
Target Species
Human
Target Name
EDEM2
Target Full Name
ER degradation-enhancing alpha-mannosidase-like protein 2
Target Function
Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins.
Target Subcellular Location
Endoplasmic reticulum lumen.
Target Protein Families
Glycosyl hydrolase 47 family
Target Tissue Specificity
Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.
Target Synonyms
bA4204.1; C20orf31; C20orf49; EDEM 2; EDEM2; EDEM2_HUMAN; ER degradation enhancer mannosidase alpha like 2; ER degradation enhancing alpha mannosidase like 2; ER degradation enhancing alpha mannosidase like protein 2; ER degradation enhancing mannosidase like protein 2; ER degradation-enhancing alpha-mannosidase-like 2; FLJ10783; UNQ573/PRO1135
Target Background
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).
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