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The antibody against ERAP2 was raised in rabbit using the Recombinant Human Endoplasmic reticulum aminopeptidase 2 protein (406-522AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against ERAP2 was raised in rabbit using the Recombinant Human Endoplasmic reticulum aminopeptidase 2 protein (406-522AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-02249A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ERAP2 |
| Target Synonyms | ERAP2 antibody; LRAPEndoplasmic reticulum aminopeptidase 2 antibody; EC 3.4.11.- antibody; Leukocyte-derived arginine aminopeptidase antibody; L-RAP antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Endoplasmic reticulum aminopeptidase 2 protein (406-522AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6P179 |
Uniprot Id
Q6P179
Target Species
Human
Target Name
ERAP2
Target Full Name
Endoplasmic reticulum aminopeptidase 2
Target Function
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Target Protein Families
Peptidase M1 family
Target Tissue Specificity
Ubiquitously expressed. Highly expressed in spleen and leukocytes.
Target Synonyms
ERAP2; LRAPEndoplasmic reticulum aminopeptidase 2; EC 3.4.11.-; Leukocyte-derived arginine aminopeptidase; L-RAP
Target Background
This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5.
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