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The antibody against ESX1 was raised in rabbit using the Human ESX1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against ESX1 was raised in rabbit using the Human ESX1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$600.00
| Cat.No | ADC-48616A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ESX1 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.02% sodium azide |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Human ESX1 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N693 |
Uniprot Id
Q8N693
Target Species
Human
Target Name
ESX1
Target Full Name
Homeobox protein ESX1
Target Function
May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.
Target Subcellular Location
Cytoplasm. Nucleus. Note=ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
Target Tissue Specificity
Expressed in placenta and testis. Expressed in testicular germ cell tumors.
Target Synonyms
ESX1; ESX1L; ESX1R; Homeobox protein ESX1; Extraembryonic; spermatogenesis; homeobox 1) [Cleaved into: Homeobox protein ESX1-N; Homeobox protein ESX1-C]
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