Rabbit anti-Human FBXO18 Polyclonal Antibody

Uniprot Id

Q8NFZ0

Target Species

Human

Target Name

FBH1

Target Full Name

F-box DNA helicase 1

Target Function

3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress. Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal. In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location.

Target Involvement

Defects in FBXO18 are frequently observed in melanomas, resulting in increased survival in response to replicative stress. Its inactivation may play a role in oncogenic transformation.

Target Subcellular Location

Nucleus. Chromosome.

Target Protein Families

Helicase family, UvrD subfamily

Target Synonyms

F box DNA helicase 1 ; F box only protein 18; F box only protein helicase 18; F box protein, helicase, 18; F-box DNA helicase 1; F-box only protein 18; FBH1; Fbx18; FBX18_HUMAN; Fbxo18; FLJ14590; MGC131916; MGC141935; MGC141937