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The antibody against FCHSD2 was raised in rabbit using the Recombinant Human F-BAR and double SH3 domains protein 2 protein (1-290AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against FCHSD2 was raised in rabbit using the Recombinant Human F-BAR and double SH3 domains protein 2 protein (1-290AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human small intestine tissue using FCHSD2 Antibody at dilution of 1:1002
| Cat.No | ADC-24876A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FCHSD2 |
| Target Synonyms | FCHSD2 antibody; KIAA0769 antibody; SH3MD3F-BAR and double SH3 domains protein 2 antibody; Carom antibody; Protein nervous wreck 1 antibody; NWK1 antibody; SH3 multiple domains protein 3 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human F-BAR and double SH3 domains protein 2 protein (1-290AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O94868 |
Uniprot Id
O94868
Target Species
Human
Target Name
FCHSD2
Target Full Name
F-BAR and double SH3 domains protein 2
Target Function
Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes.
Target Subcellular Location
Cytoplasm. Cell junction. Membrane, clathrin-coated pit. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium.
Target Tissue Specificity
Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney.
Target Synonyms
FCHSD2; KIAA0769; SH3MD3F-BAR and double SH3 domains protein 2; Carom; Protein nervous wreck 1; NWK1; SH3 multiple domains protein 3
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