Rabbit anti-Human FCRL4 Polyclonal Antibody

Uniprot Id

Q96PJ5

Target Species

Human

Target Name

FCRL4

Target Full Name

Fc receptor-like protein 4

Target Function

May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.

Target Involvement

A chromosomal aberration involving FCRL4 is found in non-Hodgkin lymphoma (NHG). Translocation t(1;1)(p36.3; q21.1-2).

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Specifically expressed by memory and monocytoid B-cells which populate spleen and lymph nodes. Preferentially expressed in memory B-cells associated with mucosal tissue (at protein level).

Target Research Area

Immunology

Target Synonyms

CD307d; Fc receptor homolog 4; Fc receptor like 4; Fc receptor like protein 4; Fc receptor-like protein 4; FcR like protein 4; FcR-like protein 4; FcRH4; FcRL4; FCRL4_HUMAN; hIFGP2; IFGP family protein 2; IGFP2; Immune receptor translocation associated protein 1; Immune receptor translocation-associated protein 1; Immunoglobulin superfamily receptor translocation associated 1; Immunoglobulin superfamily receptor translocation associated gene 1; IRTA1

Target Background

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma.