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The antibody against FGD5 was raised in rabbit using the Recombinant Human FYVE, RhoGEF and PH domain-containing protein 5 protein (269-539AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against FGD5 was raised in rabbit using the Recombinant Human FYVE, RhoGEF and PH domain-containing protein 5 protein (269-539AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human lung tissue using FGD5 Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using FGD5 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-15300A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FGD5 |
| Target Synonyms | FGD5 antibody; ZFYVE23FYVE antibody; RhoGEF and PH domain-containing protein 5 antibody; Zinc finger FYVE domain-containing protein 23 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human FYVE, RhoGEF and PH domain-containing protein 5 protein (269-539AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6ZNL6 |
Uniprot Id
Q6ZNL6
Target Species
Human
Target Name
FGD5
Target Full Name
FYVE, RhoGEF and PH domain-containing protein 5
Target Function
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
Target Subcellular Location
Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Endoplasmic reticulum. Golgi apparatus. Early endosome. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.
Target Tissue Specificity
Expressed in endothelial cells (at protein level).
Target Synonyms
FGD5; ZFYVE23FYVE; RhoGEF and PH domain-containing protein 5; Zinc finger FYVE domain-containing protein 23
Target Background
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including filopodium assembly; regulation of GTPase activity; and regulation of cell shape. Located in plasma membrane.
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