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The antibody against GALC was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human GALC (NP_000144.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against GALC was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human GALC (NP_000144.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-04041A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GALC |
| Target Synonyms | GALC | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, A375, DU145, HepG2, Mouse brain, Rat testis | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human GALC (NP_000144.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P54803 | Immunogen Sequence |
Uniprot Id
P54803
Target Species
Human
Target Name
GALC
Target Full Name
Galactocerebrosidase
Target Function
Hydrolyzes the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
Target Involvement
Leukodystrophy, globoid cell (GLD)
Target Subcellular Location
Lysosome.
Target Protein Families
Glycosyl hydrolase 59 family
Target Tissue Specificity
Detected in urine. Detected in testis, brain and placenta (at protein level). Detected in kidney and liver.
Target Research Area
Cardiovascular
Target Synonyms
Gacy; Galactocerebrosidase; Galactocerebroside beta galactosidase; Galactocerebroside beta-galactosidase; Galactosylceramidase; Galactosylceramide beta galactosidase; Galactosylceramide beta-galactosidase; galactosylceraminidase; GALC; GALC_HUMAN; GALCERase; Twitcher
Target Background
This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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