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The antibody against GATAD2B was raised in rabbit using the Recombinant Human Transcriptional repressor p66-beta protein (58-146AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against GATAD2B was raised in rabbit using the Recombinant Human Transcriptional repressor p66-beta protein (58-146AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-04750A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GATAD2B |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Transcriptional repressor p66-beta protein (58-146AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8WXI9 |
Uniprot Id
Q8WXI9
Target Species
Human
Target Name
GATAD2B
Target Full Name
Transcriptional repressor p66-beta
Target Function
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development.
Target Involvement
Mental retardation, autosomal dominant 18 (MRD18)
Target Subcellular Location
Nucleus speckle.
Target Tissue Specificity
Widely expressed.
Target Synonyms
FLJ37346; GATA zinc finger domain containing 2B; GATA zinc finger domain containing protein 2B ; GATA zinc finger domain-containing protein 2B; GATAD2B; KIAA1150; MGC138257; MGC138285; mKIAA1150; p66/p68; P66B_HUMAN; P66beta; RGD1308533; transcription repressor p66 beta component of the MeCP1 complex; Transcriptional repressor p66 beta; Transcriptional repressor p66-beta
Target Background
This gene encodes a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with cognitive disability.
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