Rabbit anti-Human GDF9 Polyclonal Antibody

Uniprot Id

O60383

Target Species

Human

Target Name

GDF9

Target Full Name

Growth/differentiation factor 9

Target Function

Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.

Target Involvement

Altered GDF9 function may be involved in ovarian disorders. Rare variants in GDF9 have been found in patients with premature ovarian failure and mothers of dizygotic twins.

Target Subcellular Location

Secreted.

Target Protein Families

TGF-beta family

Target Tissue Specificity

Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level).

Target Research Area

Cardiovascular

Target Synonyms

GDF9Growth/differentiation factor 9; GDF-9

Target Background

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates ovarian function. Reduced expression of this gene may be associated with polycystic ovary syndrome and mutations in this gene may be more common in mothers of dizygotic twins.