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The antibody against GNB4 was raised in rabbit using the Recombinant Human Guanine nucleotide-binding protein subunit beta-4 protein (105-185AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against GNB4 was raised in rabbit using the Recombinant Human Guanine nucleotide-binding protein subunit beta-4 protein (105-185AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human pancreatic cancer using GNB4 Antibody at dilution of 1:1002
| Cat.No | ADC-11638A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GNB4 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Guanine nucleotide-binding protein subunit beta-4 protein (105-185AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9HAV0 |
Uniprot Id
Q9HAV0
Target Species
Human
Target Name
GNB4
Target Full Name
Guanine nucleotide-binding protein subunit beta-4
Target Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Target Involvement
Charcot-Marie-Tooth disease, dominant, intermediate type, F (CMTDIF)
Target Protein Families
WD repeat G protein beta family
Target Tissue Specificity
Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves.
Target Synonyms
G protein beta 4 subunit; GBB4_HUMAN; GNB 4; Gnb4; Guanine nucleotide binding protein (G protein) beta polypeptide 4; Guanine nucleotide binding protein beta 4 subunit; Guanine nucleotide binding protein beta polypeptide 4; Guanine nucleotide binding protein beta subunit 4; Guanine nucleotide binding protein subunit beta 4; Guanine nucleotide-binding protein subunit beta-4; Transducin beta chain 4
Target Background
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.
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