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The antibody against GNE was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human GLCNE. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
The antibody against GNE was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human GLCNE. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
$167.00
Western Blot analysis of 3T3 cells using GLCNE Polyclonal Antibody
| Cat.No | ADC-36704A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GNE |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the C-terminal region of Human GLCNE. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y223 |
Uniprot Id
Q9Y223
Target Species
Human
Target Name
GNE
Target Full Name
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Target Function
Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essential role in early development. Required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells.
Target Involvement
Sialuria (SIALURIA); Nonaka myopathy (NM)
Target Subcellular Location
Cytoplasm.
Target Protein Families
UDP-N-acetylglucosamine 2-epimerase family; ROK (NagC/XylR) family
Target Tissue Specificity
Highest expression in liver and placenta. Also found in heart, brain, lung, kidney, skeletal muscle and pancreas. Isoform 1 is expressed in heart, brain, kidney, liver, placenta, lung, spleen, pancreas, skeletal muscle and colon. Isoform 2 is expressed ma
Target Research Area
Cardiovascular
Target Synonyms
2310066H07Rik; Bifunctional UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase; DMRV; GLCNE_HUMAN; Glucosamine (UDP N acetyl) 2 epimerase/N acetylmannosamine kinase; GNE; IBM2; ManAc kinase; N acylmannosamine kinase; N-acetylmannosamine kinase; NM; RP23-209M8.6; Uae1; UDP GlcNAc 2 epimerase; UDP GlcNAc 2 epimerase/ManAc kinase; UDP N acetylglucosamine 2 epimerase/N acetylmannosamine kinase; UDP-GlcNAc-2-epimerase; UDP-GlcNAc-2-epimerase/ManAc kinase; Uridine diphosphate N acetylglucosamine 2 epimerase; Uridine diphosphate-N-acetylglucosamine-2-epimerase
Target Background
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.
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