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The antibody against GPR68 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 276-365 of human GPR68 (NP_003476.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against GPR68 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 276-365 of human GPR68 (NP_003476.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-15885A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GPR68 |
| Target Synonyms | OGR1; AI2A6; GPR12A; 68 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | NIH/3T3, Rat brain, 293T, HL-60, Jurkat, Mouse brain, Mouse lung, Mouse spleen, U-87MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 276-365 of human GPR68 (NP_003476.3). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | SFNCVADPVLYCFVSETTHRDLARLRGACLAFLTCSRTGRAREAYPLGAPEASGKSGAQGEEPELLTKLHPAFQTPNSPGSGGFPTGRLA | Uniprot ID | Q15743 |
Uniprot Id
Q15743
Target Species
Human
Target Name
GPR68
Target Full Name
Ovarian cancer G-protein coupled receptor 1
Target Function
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer.
Target Involvement
Amelogenesis imperfecta, hypomaturation type, 2A6 (AI2A6)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family
Target Tissue Specificity
Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.
Target Synonyms
GPR68; OGR1; Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A; Sphingosylphosphorylcholine receptor
Target Background
The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta.
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