Rabbit anti-Human HARS Polyclonal Antibody

Uniprot Id

P12081

Target Species

Human

Target Name

HARS1

Target Full Name

Histidine--tRNA ligase, cytoplasmic

Target Function

Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance.

Target Involvement

Usher syndrome 3B (USH3B); Charcot-Marie-Tooth disease 2W (CMT2W)

Target Subcellular Location

Cytoplasm.

Target Protein Families

Class-II aminoacyl-tRNA synthetase family

Target Tissue Specificity

Brain, heart, liver and kidney.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

cytoplasmic; EC 6.1.1.21 ; FLJ20491 ; HARS; HisRS; Histidine tRNA ligase, cytoplasmic; histidine translase; Histidine tRNA ligase; Histidine--tRNA ligase; Histidyl tRNA synthetase ; Histidyl-tRNA synthetase; HRS ; Human histidyl tRNA synthetase homolog (HO3) mRNA complete cds; SYHC_HUMAN; USH3B

Target Background

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene.